THE BIOSYNTHESIS OF CARBOCYCLIC NUCLEOSIDES

Authors
JENKINS GN TURNER NJ
Citation
Gn. Jenkins et Nj. Turner, THE BIOSYNTHESIS OF CARBOCYCLIC NUCLEOSIDES, Chemical Society reviews, 24(3), 1995, pp. 169-176
Citations number
41
Categorie Soggetti
Chemistry
Journal title
Chemical Society reviews → ACNP
ISSN journal
03060012
Volume
24
Issue
3
Year of publication
1995
Pages
169 - 176
Database
ISI
SICI code
0306-0012(1995)24:3<169:TBOCN>2.0.ZU;2-O
Abstract
Aristeromycin and neplanocin A are two naturally occurring carbocyclic nucleosides isolated from Streptomyces citricolor. They belong to a s mall family of cyclopentane-containing natural products that are deriv ed from carbohydrates, in this case D-glucose, as the ultimate biosynt hetic precursor. This review outlines our current understanding of the biosynthesis of aristeromycin and neplanocin and proposes possible me chanisms for the conversion of carbohydrates into 5-membered ring carb ocycles.