TETRAHYDROAMINOACRIDINE MODULATES TC-99M LABELED ETHYLENE DICYSTEINATE RETENTION IN ALZHEIMERS-DISEASE MEASURED WITH SINGLE-PHOTON EMISSIONCOMPUTED-TOMOGRAPHY IMAGING

Authors
RIEKKINEN P KUIKKA J SOININEN H HELKALA EL HALLIKAINEN M RIEKKINEN P
Citation
P. Riekkinen et al., TETRAHYDROAMINOACRIDINE MODULATES TC-99M LABELED ETHYLENE DICYSTEINATE RETENTION IN ALZHEIMERS-DISEASE MEASURED WITH SINGLE-PHOTON EMISSIONCOMPUTED-TOMOGRAPHY IMAGING, Neuroscience letters, 195(1), 1995, pp. 53-56
Citations number
15
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
195
Issue
1
Year of publication
1995
Pages
53 - 56
Database
ISI
SICI code
0304-3940(1995)195:1<53:TMTLED>2.0.ZU;2-3
Abstract
The present study investigated if acute treatment with tetrahydroamino acridine (THA) (25 or 75 mg, p.o.) affects technetium-99m labelled eth ylene dicysteinate (ECD) retention abnormalities in patients with mild to moderate Alzheimer's disease (AD; mean age 69 years). THA (75 mg) increased temporal, prefrontal and occipital ECD retention (normalized to cerebellum) in mildly demented AD patients, but 25 mg of THA had n o effect on ECD retention. After 75 mg THA, prefrontal and temporal EC D retention correlated with improved executive and memory functioning, respectively. THA (25 or 75 mg) had no measurable effect on ECD reten tion of moderately demented patients.