INTRODUCTION OF A TERMINAL HYDROXY GROUP INTO THE LIPID PART OF A MOENOMYCIN-TYPE TRANSGLYCOSYLASE INHIBITOR SUPPRESSES ANTIBIOTIC-ACTIVITY

Authors
KEMPIN U HENNIG L WELZEL P MARZIAN S MULLER D FEHLHABER HW MARKUS A VANHEIJENOORT Y VANHEIJENOORT J
Citation
U. Kempin et al., INTRODUCTION OF A TERMINAL HYDROXY GROUP INTO THE LIPID PART OF A MOENOMYCIN-TYPE TRANSGLYCOSYLASE INHIBITOR SUPPRESSES ANTIBIOTIC-ACTIVITY, Tetrahedron, 51(31), 1995, pp. 8471-8482
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
51
Issue
31
Year of publication
1995
Pages
8471 - 8482
Database
ISI
SICI code
0040-4020(1995)51:31<8471:IOATHG>2.0.ZU;2-Z
Abstract
On reaction with singlet oxygen 1 provided a mixture of 2 and 3 which could not be separated. In-vivo, 2/3 were antibiotically of low activi ty whereas in the in-vitro assays at least one of the compounds inhibi ted the transglycosylase effectively.