STRUCTURE OF THE PROMOTER FOR THE HUMAN MACROPHAGE STIMULATING PROTEIN-RECEPTOR GENE

The macrophage stimulating protein receptor is a receptor protein tyro sine kinase of the met/hepatocyte growth factor receptor family. Bindi ng of the macrophage stimulating protein to its receptor provokes chan ges in cell morphology and motility. Here we report the structure of t he promoter of the gene coding for this receptor. The major transcript ion start sites have been identified. The 5' flanking region has chara cteristics of other receptor tyrosine kinase gene promoters, namely se veral GC boxes but the absence of a TATA box. Deletion analysis shows that multiple elements are needed for full promoter activity.