IDENTIFICATION AND ANALYSIS OF A YOUNG POLYMORPHIC ALU ELEMENT

Authors
ARCOT SS FONTIUS JJ DEININGER PL BATZER MA
Citation
Ss. Arcot et al., IDENTIFICATION AND ANALYSIS OF A YOUNG POLYMORPHIC ALU ELEMENT, Biochimica et biophysica acta, N. Gene structure and expression, 1263(1), 1995, pp. 99-102
Citations number
24
Categorie Soggetti
Biology,Biophysics,"Biothechnology & Applied Migrobiology
Journal title
Biochimica et biophysica acta, N. Gene structure and expression → ACNP
ISSN journal
01674781
Volume
1263
Issue
1
Year of publication
1995
Pages
99 - 102
Database
ISI
SICI code
0167-4781(1995)1263:1<99:IAAOAY>2.0.ZU;2-O
Abstract
A polymorphic Alu element belonging to a young subfamily of Alu repeat s has been identified. Sequence analysis showed that this Alu element is flanked by perfect direct repeats and a 3' oligo(dA)-rich tail, The Alu element, designated A25, is deleted by 34 nucleotides at the 5' e nd and has a single CpG mutation compared to the human-specific consen sus sequence. Using a PCR-based assay, we demonstrated that the A25 Al u repeat is localized to human chromosome 8 and is polymorphic in huma ns.