Developments in technology mean that it is now possible to localize ab
normal parathyroid glands by a variety of imaging methods. There remai
n a number of unresolved issues. With all commonly used methods (radio
nuclide imaging, ultrasound, computed tomography and magnetic resonanc
e imaging), there are wide variations in sensitivity of detection of g
lands, and in many cases this variation is not explained satisfactoril
y. The necessity for imaging is questioned by many parathyroid surgeon
s, particularly before a first operation. However, parathyroid surgery
is itself changing, with a trend towards more limited neck exploratio
n, which requires localization of the glands pre-operatively. This rev
iew describes the methods available for localizing parathyroid glands,
with their advantages and limitations, and discusses the role of the
techniques prior to surgery.