MURICATOCIN-A AND MURICATOCIN-B, 2 NEW BIOACTIVE MONOTETRAHYDROFURAN ANNONACEOUS ACETOGENINS FROM THE LEAVES OF ANNONA-MURICATA

The leaves of Annona muricata have yielded the novel monotetrahydrofur an Annonaceous acetogenins, muticatocins A [1] and B [2]. Each compoun d possesses five hydroxyl groups, with two hydroxyl groups at the C-10 and C-12 positions. The absolute configurations of 1 and 2 (except fo r positions C-10 and C-12) were determined by Mosher ester methodology . The C-10, C-12 acetonides (1c, 2c) suggested relative stereochemistr y and significantly enhanced cytotoxicity against the A-549 human lung tumor cell line. Three known monotetrahydrofuran acetogenins, annonac in A, (2,4-trans)-isoannonacin, and (2,4-cis)-isoannonacin, were also found.