NEW BIOACTIVE MONOTETRAHYDROFURAN ANNONACEOUS ACETOGENINS, ANNOMURICIN-C AND MURICATOCIN-C, FROM THE LEAVES OF ANNONA-MURICATA

The leaves of Annona muricata have yielded two additional monotetrahyd rofuran Annonaceous acetogenins, annomuricin C [1] and muricatocin C [ 2]. Compounds 1 and 2 each possess five hydroxyl groups; two hydroxyl groups are at the C-10/C-11 and C-10/C-12 positions in 1 and 2, respec tively. The absolute configurations of 1 and 2, except for positions C -10 and C-11 or C-12, were determined by Mosher ester methodology. The C-10/C-11 and C-10/C-12 acetonides (1c, 2c) suggested relative stereo chemistry and significantly enhanced the cytotoxicities against the A- 549 human lung and the MCF-7 human beast solid tumor cell lines. One k nown monotetrahydrofuran acetogenin, giganterronenin, not described pr eviously from this plant, was also found.