Authors
Citation
Nk. Gulavita et al., APLYSILLIN-A, A THROMBIN RECEPTOR ANTAGONIST FROM THE MARINE SPONGE APLYSINA-FISTULARIS-FULVA, Journal of natural products, 58(6), 1995, pp. 954-957
Citations number
15
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
ISSN journal
01633864
Volume
58
Issue
6
Year of publication
1995
Pages
954 - 957
Database
ISI
SICI code
0163-3864(1995)58:6<954:AATRAF>2.0.ZU;2-R
Abstract
Aplysillin A [1], an unusual disulfate ester of a 1,4-diphenyl-1,3-but
adiene, was isolated from a deep water specimen of a sponge of the gen
us Aplysina. Its structure was determined through spectroscopic method
s. The compound weakly inhibited binding to the thrombin receptor with
an IC50 value of 20 mu M.