BIS(SULFATO)-CYCLOSIPHONODICTYOL-A, A NEW DISULFATED SESQUITERPENE-HYDROQUINONE FROM A DEEP-WATER COLLECTION OF THE MARINE SPONGE SIPHONODICTYON-CORALLIPHAGUM

A new compound, dir(sulfato)-cyclosiphonodictyol A [1], which inhibits the binding of [H-3]-LTB(4) to intact human neutrophils with an IC50 value of 44 mu M, was isolated from the sponge Siphonodictyon corallip hagum. The sponge was collected using the Johnson-Sea-Link manned subm ersible at a depth of 195 feet in the Bahamas. The compound was isolat ed via reversed-phase chromatography and its structure determined spec troscopically. To the best of our knowledge, 1 is the first marine-der ived compound with two aromatic sulfate ester functionalities, and is also the first in the siphonodictyal series to contain an oxepane func tionality.