METABOLIC-ACIDOSIS IN THE ALCOHOLIC - AN EMPHASIS ON INTRACELLULAR EVENTS

The focus of this review will be to examine the subject of metabolic a cidosis in the alcoholic, emphasing intracellular events. In this rega rd, two points shall be highlighted: first, ''metabolic'' aspects of m etabolic acidosis and their quantitative implications; and second, we will highlight factors that impact on the severity of intracellular ac idosis and the titration of intracellular proteins. This approach shou ld provide a better understanding of the pathophysiology of the metabo lic acid-base disorders in these patients, and could indicate where le verage should be exerted in therapy.