Between October 1986 and May 1994, 65 patients undergoing cardiac surg
ery required centrifugal mechanical assist devices to separate from ca
rdiopulmonary bypass, This experience was arbitrarily divided into ear
ly (n = 33) and recent (n = 32) groups for the purpose of comparing tr
ends in morbidity and mortality. The incidence of mechanical assist ap
plication decreased from 2.19% in the early group to 0.96% in the rece
nt group (p < 0.0001), Ability to wean patients from centrifugal assis
t increased from 33% in the early group to 53% in the more recent grou
p, and hospital survival increased from 15 to 28%. The median chest tu
be drainage during the first 24 h decreased from 3,245 mi to 1,535 mi,
and the incidence of renal failure decreased from 39.4% and 18.8% in
the more recent group. Clinically relevant improvement in patient outc
ome following application of centrifugal mechanical assist for postcar
diotomy ventricular failure is being observed.