V. Engelbrecht et al., MRI OF THE BRAIN IN WILSON DISEASE - T2 SIGNAL LOSS UNDER THERAPY, Journal of computer assisted tomography, 19(4), 1995, pp. 635-638
Repeat examinations in a de novo patient with Wilson disease revealed
an expansion of decreased signal intensities in the basal ganglia on T
2-weighted imaging after initiation of copper trapping therapy. Since
marked clinical improvement was associated with continued urinary copp
er excretion, iron depositioning in exchange for copper might explain
these findings.