We report an unusual case of biopsy-proven combined leptomeningeal and
calvarial sarcoidosis, as seen on CT and MRI. A solitary large thick
plaque was present in the left hemisphere, with overlying bony infiltr
ation and erosion and associated abundant vasogenic edema in the brain
. The lytic lesion was visible on Scout digital radiography for CT sli
ce positioning. The typical manifestations of CNS sarcoidosis, i.e., c
hronic leptomeningitis in the basilar cisterns and hypothalamic region
s, were absent.