A. Horiguchi et K. Mochida, ENZYMATIC OPTICAL RESOLUTION OF N-BENZYL-3-PYRROLIDINOL, Bioscience, biotechnology, and biochemistry, 59(7), 1995, pp. 1287-1290
The enzymatic optical resolution of racemic N-benzyl-3-pyrrolidinol (2
) was investigated. It was found that only (R)-2 was acetylated by the
lipase Amano P in yields of 50% and 100%e.e. Remaining (S)-alcohol 2
could be chemically inverted to (R)-acetate 3. A continuous reaction i
n a column reactor could be also applied to this optical resolution. A
fter concentrating the eluted solution, the residue was subjected to t
he inversion reaction to provide (R)-acetate 3 in an 83% yield and 91%
e.e. from the racemate.