T. Dairi et al., CONSERVED ORGANIZATION OF GENES FOR BIOSYNTHESIS OF CHLORTETRACYCLINEIN STREPTOMYCES STRAINS, Bioscience, biotechnology, and biochemistry, 59(7), 1995, pp. 1360-1361
By genomic Southern blot analysis, the DNA sequences homologous to the
gene cluster responsible for biosynthesis of 6-demethyl-chlortetracyc
line in Streptomyces aureofaciens NRRL3203 mere shown to be highly con
served in independent chlortetracycline- or tetracycline producing Str
eptomyces strains. By contrast, oxytetracycline-producing Streptomyces
strains had no hybridization with the cluster DNA.