CAPILLARY ELECTROPHORETIC SEPARATION OF BASIC DRUGS USING SURFACE-MODIFIED C-8 CAPILLARIES AND DERIVATIZED CYCLODEXTRINS AS STRUCTURAL CHIRAL SELECTORS

Dynamic coating of bonded Cs fused silica capillaries with cationic am phiphiles is shown to minimize adsorption of basic drug molecules but also to facilitate control/reversal of electroosmotic flow. Optimizati on of the peak shapes was achieved by addition of cationic amphiphiles with a suitable mobility and adsorption to the capillary surface. The surface modification described, combined with the addition of cyclode xtrins as selectors into the background electrolyte, resulted in uniqu e CE systems showing excellent resolution for structural analogues. Th e separation of rotamers and enantiomers is demonstrated. Applications to the antipsychotic compound remoxipride and its related substances and to the chiral separation of asthma- and local anaesthetic drug ena ntiomers are given.