VITAMIN-A SUPPLEMENTATION, MORBIDITY, AND SERUM ACUTE-PHASE PROTEINS IN YOUNG GHANAIAN CHILDREN

The association of vitamin A supplementation with concentrations of po sitive acute-phase proteins in the serum was investigated in the Child Health Study of the Ghana Vitamin A Supplementation Trials, a randomi zed, controlled trial of the effect of vitamin A on morbidity in child ren aged < 5 y. Mean serum concentrations of alpha(1)-acid glycoprotei n, serum amyloid A, and C-reactive protein did not differ overall betw een the vitamin A-supplemented and placebo-treated groups. Treatment g roups were then subdivided according to what symptoms children had exp erienced in the week before blood sampling. Acute-phase-protein respon ses to fever and cough were not affected by vitamin A supplementation. There was a tendency for vitamin A-supplemented children, but not pla cebo children, to have elevated acute-phase proteins in association wi th reported vomiting or severe diarrhea. The failure of unsupplemented children to mount an acute-phase response may have contributed to the ir increased morbidity from gastrointestinal symptoms.