Backpropagation neural networks have been applied ;to prediction and c
lassification problems in many real world situations. However, a drawb
ack of this type of neural network is that it requires a full set of i
nput data, and real world data is seldom complete. We have investigate
d two ways of dealing with incomplete data - network reduction using m
ultiple neural network classifiers, and value substitution using estim
ated values from predictor networks and compared their performance wit
h an induction method. On a thyroid disease database collected in a cl
inical situation, we found that the network reduction method was super
ior. We conclude that network reduction can be a useful method for dea
ling with missing values in diagnostic systems based on backpropagatio
n neural networks.