Pd. Hockings et al., CORRELATION BETWEEN HIGH-FIELD T2-WEIGHTED MR-IMAGING AND HISTOLOGY OF ISCHEMIC LESIONS IN GERBIL BRAIN, Journal of magnetic resonance imaging, 5(4), 1995, pp. 437-442
Global forebrain ischemia in the Mongolian gerbil is a common animal m
odel for use in stroke research. We produced lesions of graded severit
y in gerbil brains [after prescreening by MR imaging] by performing 6-
minute bilateral carotid artery occlusions while monitoring pericrania
l temperature with a temporalis muscle thermocouple probe and maintain
ing the temperature at 32 degrees C, 36 degrees C, or 40 degrees C. Le
sion severity was scored 4 days after occlusion from findings on spin-
echo images acquired at 7 T and from histologic scores. Statistically
significant correlation was observed between the MR imaging score and
brain temperature and between the MR imaging score and the area of the
CA region of the hippocampus measured by histology. In addition, beca
use prescreening with MR imaging revealed abnormalities in the hippoca
mpus of some of the animals, and these animals were rejected from the
study, the statistical significance of the result could be strengthene
d.