OVARIAN ACTIVITY DURING FOLLICULAR-PHASE DOWN-REGULATION IN IN-VITRO FERTILIZATION IS ASSOCIATED WITH ADVANCED MATERNAL AGE AND A HIGH RECURRENCE RATE IN SUBSEQUENT CYCLES
Dr. Session et al., OVARIAN ACTIVITY DURING FOLLICULAR-PHASE DOWN-REGULATION IN IN-VITRO FERTILIZATION IS ASSOCIATED WITH ADVANCED MATERNAL AGE AND A HIGH RECURRENCE RATE IN SUBSEQUENT CYCLES, Journal of assisted reproduction and genetics, 12(5), 1995, pp. 301-304
Purpose: Previous reports have suggested that the ovarian response to
leuprolide acetate is predictive of in vitro fertilization pregnancy r
ates. This study evaluated the outcome of in vitro fertilization cycle
s complicated by elevated estradiol levels during leuprolide acetate d
own regulation and the outcome of subsequent cycles in the same patien
ts. Methods: Two hundred fifty-two in vitro fertilization cycles were
initiated utilizing leuprolide acetate down regulation beginning on cy
cle day 1. Results: Seventy-four of these cycles had an elevated estra
diol level at the time of the baseline scan (28%). This group of patie
nts had a higher maternal age, a higher cycle cancellation rate (27.5
vs 16.3%), and a high rate of recurrence on subsequent cycles (63%). C
onclusions: The pregnancy rate per retrieval was equivalent in the two
groups. This suggests that patients with advanced maternal age or a h
istory of failure to suppress in a previous cycle may benefit from alt
ernate regimens of superovulation.