SPERM STIMULANTS CAN IMPROVE FERTILIZATION RATES IN MALE-FACTOR CASESUNDERGOING IVF TO THE SAME EXTENT AS MICROMANIPULATION BY PARTIAL ZONA DISSECTION (PZD) OR SUBZONAL SPERM INSEMINATION (SUZI) - A RANDOMIZED CONTROLLED-STUDY
Wr. Edirisinghe et al., SPERM STIMULANTS CAN IMPROVE FERTILIZATION RATES IN MALE-FACTOR CASESUNDERGOING IVF TO THE SAME EXTENT AS MICROMANIPULATION BY PARTIAL ZONA DISSECTION (PZD) OR SUBZONAL SPERM INSEMINATION (SUZI) - A RANDOMIZED CONTROLLED-STUDY, Journal of assisted reproduction and genetics, 12(5), 1995, pp. 312-318
Purpose Our purpose was to evaluate the efficacy of direct inseminatio
n (IVF), micromanipulation by partial zona dissection (PZD), and subzo
nal sperm insemination (SUZI) using sperm-treated with pentoxifylline
(PF) +/- 2-deoxyadenosine (2DA). Results: The overall fertilization ra
te achieved was similar for all three fertilization techniques (33.1,
30.2, and 26.9% for IVF, SUZI, and PZD, respectively). Patients who ha
d reduced fertilization in previous IVF attempts showed improved ferti
lization with sperm stimulants, either PF alone or PF in combination w
ith 2DA in standard IVF. In certain cases, SUZI or PZD gave significan
tly improved fertilization rates in comparison to IVF. Conclusion: Sel
ective use of sperm stimulants in IVF can achieve fertilization for th
e majority of male-factor cases. However, PZD and SUZI techniques are
useful, especially when sperm stimulants fail to achieve fertilization
or achieve poor fertilization in direct insemination.