SPERM STIMULANTS CAN IMPROVE FERTILIZATION RATES IN MALE-FACTOR CASESUNDERGOING IVF TO THE SAME EXTENT AS MICROMANIPULATION BY PARTIAL ZONA DISSECTION (PZD) OR SUBZONAL SPERM INSEMINATION (SUZI) - A RANDOMIZED CONTROLLED-STUDY

Citation
Wr. Edirisinghe et al., SPERM STIMULANTS CAN IMPROVE FERTILIZATION RATES IN MALE-FACTOR CASESUNDERGOING IVF TO THE SAME EXTENT AS MICROMANIPULATION BY PARTIAL ZONA DISSECTION (PZD) OR SUBZONAL SPERM INSEMINATION (SUZI) - A RANDOMIZED CONTROLLED-STUDY, Journal of assisted reproduction and genetics, 12(5), 1995, pp. 312-318
Citations number
NO
Categorie Soggetti
Obsetric & Gynecology
ISSN journal
10580468
Volume
12
Issue
5
Year of publication
1995
Pages
312 - 318
Database
ISI
SICI code
1058-0468(1995)12:5<312:SSCIFR>2.0.ZU;2-V
Abstract
Purpose Our purpose was to evaluate the efficacy of direct inseminatio n (IVF), micromanipulation by partial zona dissection (PZD), and subzo nal sperm insemination (SUZI) using sperm-treated with pentoxifylline (PF) +/- 2-deoxyadenosine (2DA). Results: The overall fertilization ra te achieved was similar for all three fertilization techniques (33.1, 30.2, and 26.9% for IVF, SUZI, and PZD, respectively). Patients who ha d reduced fertilization in previous IVF attempts showed improved ferti lization with sperm stimulants, either PF alone or PF in combination w ith 2DA in standard IVF. In certain cases, SUZI or PZD gave significan tly improved fertilization rates in comparison to IVF. Conclusion: Sel ective use of sperm stimulants in IVF can achieve fertilization for th e majority of male-factor cases. However, PZD and SUZI techniques are useful, especially when sperm stimulants fail to achieve fertilization or achieve poor fertilization in direct insemination.