CONCOMITANT CATHODIC CLEAVAGE OF CARBAMATES AND CARBON-BROMINE BONDS AS KEY STEPS IN THE ENZYME-INHIBITORS SYNTHESIS

The synthesis of the 4-(3-indolyl)-oxazol-2-one, a potential protein k inase C inhibitor, was performed by using electrochemistry as key step . The anodic methoxylation of an oxazolidin-2-one was achieved by this way in good yield. The high selectivity of the electrochemical method allowed then the aromatic carbon-bromine bond hydrogenolysis and the cleavage of N-oxazolone protecting group in a one-pot process simply b y adjusting the appropriate cathodic potential.