SCREENING FOR MUTATIONS AT CODON-717 OF THE AMYLOID PRECURSOR PROTEINGENE IN ALZHEIMERS-DISEASE

Three kinds of missense mutation at codon 717 of amyloid precursor pro tein (APP) gene (Val-->Ile; Val-->Gly; Val-->Phe) were screened in 114 patients with familial and sporadic Alzheimer's disease (AD), using a rapid testing method for each Val-->Gly and Val-->Phe mutation and Go ate's method for Val-->Ile mutation based on the polymerase chain reac tion. Mutations were not found in the subjects, confirming earlier sug gestions that these three mutations at codon 717 of APP gene account f or only a small proportion of cases of not only familial AD but also s poradic AD.