PROSPECTIVE RANDOMIZED CONTROLLED TRIAL OF A MICRONIZED FLAVONIDIC FRACTION TO REDUCE BLEEDING AFTER HEMORRHOIDECTOMY

A prospective randomized controlled trial was carried out on the effec ts of Daflon 500 mg (a micronized flavonidic fraction containing diosm in 450 mg and hesperidin 50 mg) on bleeding after haemorrhoidectomy. I n all, 228 consecutive patients with prolapsed irreducible piles were recruited. Elective haemorrhoidectomy was performed with a standardize d diathermy excision method. Some 114 patients were randomized to rece ive Daflon 500 mg for 1 week after operation (group 1), and there were 114 controls (group 2).