CHEMICALLY REMOVABLE DERIVATIZATION REAGENT FOR CHROMATOGRAPHY .2. 2-(1-NAPHTHYL)ETHYL 2-[1-(4-BENZYL)-PIPERAZYL]ETHANESULFONATE DIHYDROCHLORIDE

A sulfonate reagent, 2-(1-naphthyl)ethyl 2-[1-(4-benzyl)piperazyl]etha nesulfonate dihydrochloride, was synthesized for analytical derivatiza tion in liquid chromatography. The reagent has two main functions, one with a chromophore (naphthyl) for detection and the other with a subs tituted piperazine moiety for being removable after derivatization. Th e reagent was preliminarily applied to the derivatization of iodide an ion. The results indicated that the reagent can be readily removed by acid after derivatization; this favorably avoids the interference of t he excess reagent with the resulting iodide derivative for analysis.