In order to assess differences between cocaine dependence alone and co
caine dependence complicated by alcohol abuse, 34 subjects who met DSM
-III-R criteria for alcohol abuse and cocaine dependence (COC-ETOH gro
up) were compared with 39 subjects who met criteria for cocaine depend
ence only (COG-only group) with regard to demographics, substance use,
and psychopathology. There were no differences between groups in age,
race, employment or socio-economic status. The baseline depression an
d global severity scores in the COC-ETOH group were significantly high
er than in the COG-only group. The COC-ETOH group was significantly mo
re likely to experience a paranoid psychosis with cocaine use and sign
ificantly more likely to have abused additional substances in the mont
h prior to study entry. The COC-ETOH group also attended significantly
fewer medication management sessions during the 12-week trial. There
were no differences between groups in the type or frequency of Axis 1
or Axis II disorders.