The purpose of this report is to examine the association between migra
ine and personality, taking into account history of co-occurring psych
iatric disorders. Data came from an epidemiologic study of young adult
s in the Detroit, Michigan metropolitan area. Migraine, defined accord
ing to 1988 IHS criteria, and major depression and anxiety disorders w
ere ascertained by a structured diagnostic interview. Migraine was ass
ociated with neuroticism, but not with extraversion or psychoticism, m
easured by the Eysenck's Personality Questionnaire. The association re
mained significant, when sex and history of major depression and anxie
ty disorders were controlled. An excess of 25% of persons with migrain
e alone, uncomplicated by psychiatric comorbidity, scored in the highe
st quartile of neuroticism. The results suggest that migraine sufferer
s might be more vulnerable to psychopathology and poor adjustment to t
heir medical condition.