ADULT-ONSET FAMILIAL HEMIPLEGIC MIGRAINE

Familial hemiplegic migraine and its associated signs and symptoms hav e previously been well described. The condition demonstrates autosomal dominant inheritance and has been recently assigned to a locus on chr omosome 19. Previous reports of familial hemiplegic migraine have indi cated that expression always occurs early in life. We describe a patie nt who presented with multiple episodes of reversible hemiplegia follo wed by headache at the age of 75. Seven other family members were foun d to have been affected in a similar manner. We believe this case repr esents a unique description of familial hemiplegic migraine presenting in later life.