Aab. Ferraz et al., OPIOID AND NONOPIOID ANALGESIC DRUG EFFECTS ON COLON CONTRACTIONS IN MONKEYS, Digestive diseases and sciences, 40(7), 1995, pp. 1417-1419
Opioid drugs administered postoperatively for pain relief cause increa
sed frequency of nonpropulsive phasic contractions but decreased to ab
sent propulsive migrating contractions in the colon, thus importantly
influencing the duration of postoperative ileus. Ketorolac is thought
to permit earlier return of bowel function postoperatively compared to
morphine. Four monkeys had sets of three strain gauge force transduce
rs implanted on the right and left colon at laparotomy. After recovery
, animals were fasted overnight and had colon contractions recorded. A
fter a 1-hr baseline period, 200 mu g/kg morphine sulfate or 1 mg/kg k
etorolac tromethamine was injected intramuscularly and recording conti
nued. Each animal received four injections of each drug. Records were
analyzed visually for frequency of phasic and migrating contractions.
There was no difference in the frequency of phasic or migrating contra
ctions after injection of ketorolac. Morphine, as expected, increased
the frequency of phasic and decreased the frequency of migrating contr
actions in the colon. Ketorolac does not affect the frequency of colon
contractions.