RESPONSE OF BRAIN METASTASES FROM BREAST-CANCER TO MEGESTROL-ACETATE - A CASE-REPORT

A 56 year old women was treated with megestrol acetate (Megace) 40 mg p.o. q.i.d. for her cerebellar metastasis of primary adenocarcinoma of the breast. She had previously undergone two surgical resections of h er brain metastasis, and a course of radiotherapy. After failing to to lerate tamoxifen therapy, she received Megace, with marked improvement in her cerebellar tumor on CT scans. Despite good control of her brai n tumor with Megace, she developed progressive neurological symptoms t hought to be due to meningeal carcinomatosis, and died two years after initiating Megace therapy. We conclude that Megace could potentially be beneficial in some patients with brain metastases from adenocarcino ma of the breast.