PROTEINS WITH LEUCINE-RICH REPEATS

Leucine-rich repeats are short sequence motifs present in over sixty p roteins, all of which appear to be involved in protein-protein interac tions. The crystal structure of ribonuclease inhibitor demonstrated th at the repeats correspond to beta-alpha structural units. The recently determined crystal structure of the ribonuclease A-ribonuclease inhib itor complex suggests the basis for the protein-binding function of le ucine-rich repeats.