IDENTIFICATION OF 2 HIGHLY HOMOLOGOUS PRESYNAPTIC PROTEINS DISTINCTLYLOCALIZED AT THE DENDRITIC AND SOMATIC SYNAPSES

Citation
S. Takahashi et al., IDENTIFICATION OF 2 HIGHLY HOMOLOGOUS PRESYNAPTIC PROTEINS DISTINCTLYLOCALIZED AT THE DENDRITIC AND SOMATIC SYNAPSES, FEBS letters, 368(3), 1995, pp. 455-460
Citations number
23
Categorie Soggetti
Biophysics,Biology
Journal title
ISSN journal
00145793
Volume
368
Issue
3
Year of publication
1995
Pages
455 - 460
Database
ISI
SICI code
0014-5793(1995)368:3<455:IO2HHP>2.0.ZU;2-E
Abstract
Through screening of a murine brain cDNA library, we have isolated two brain specific cDNAs encoding highly homologous proteins, named 921-L and 921-S, comprised of 134 amino acids with 80% identity. Immunohist ological study with the mAbs raised against the bacterially expressed 921 proteins showed that 921-L protein is distributed at the dendritic region and 921-S at the neuronal somatic surface. Immune-electron mic roscopic study revealed that both 921 proteins are localized at the pr esynaptic terminal, indicating that the 921 proteins are differentiall y expressed at the dendritic and somatic presynapses.