METABOLIC APPROACH FOR REGULATION OF IL-1-BETA IN-VIVO

IL-1 beta, the autoantibodies to IL-1 beta and IL-1 beta-containing im mune complex in pleural effusion and cerebrospinal fluid were detected using anti-recombinant human IL-1 beta monoclonal antibody. The resul ts indicate that IL-1 beta is detectable in some cases, and the amount s decrease gradually with the chemotherapy following the autoantibodie s and the specific detectable immune complex. These autoantibodies may have a feedback effect, inhibiting the IL-1 beta activity, and formin g the immune complex to speed the clearance of activated IL-1 beta.