DETECTION OF 1-PHENYL-N-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE AND 1-PHENYL-1,2,3,4-TETRAHYDROISOQUINOLINE IN HUMAN BRAIN BY GAS CHROMATOGRAPHY-TANDEM MASS-SPECTROMETRY

Authors
KAJITA M NIWA T FUJISAKI M UEKI M NIIMURA K SATO M EGAMI K NAOI M YOSHIDA M NAGATSU T
Citation
M. Kajita et al., DETECTION OF 1-PHENYL-N-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE AND 1-PHENYL-1,2,3,4-TETRAHYDROISOQUINOLINE IN HUMAN BRAIN BY GAS CHROMATOGRAPHY-TANDEM MASS-SPECTROMETRY, Journal of chromatography B. Biomedical applications, 669(2), 1995, pp. 345-351
Citations number
21
Categorie Soggetti
Chemistry Analytical","Biochemical Research Methods
Journal title
Journal of chromatography B. Biomedical applications
ISSN journal
15726495 → ACNP
Volume
669
Issue
2
Year of publication
1995
Pages
345 - 351
Database
ISI
SICI code
Abstract
1-Phenyl-N-methyl-1,2,3,4-tetrahydroisoquinoline and 1-phenyl-1,2,3,4- tetrahydroisoquinoline were detected for the first time in parkinsonia n human brain using gas chromatography-tandem mass spectrometry (GC-MS -MS). Since these compounds are structural analogues of 1-methyl-4-phe nyl-1,2,3,6-tetrahydropyridine (MPTP) that produces parkinsonism in hu mans, they might be candidates for endogenous MPTP-like neurotoxins.