3-AMINO-4H-PYRIDO[4,3-E]-1,2,4-THIADIAZINE 1,1-DIOXIDE MONOHYDRATE AND 3-TERT-BUTYL-4H-PYRIDO[4,3-E]-1,2,4-THIADIAZINE 1,1-DIOXIDE

Authors
DUPONT L PIROTTE B DETULLIO P MASEREEL B DELARGE J
Citation
L. Dupont et al., 3-AMINO-4H-PYRIDO[4,3-E]-1,2,4-THIADIAZINE 1,1-DIOXIDE MONOHYDRATE AND 3-TERT-BUTYL-4H-PYRIDO[4,3-E]-1,2,4-THIADIAZINE 1,1-DIOXIDE, Acta crystallographica. Section C, Crystal structure communications, 51, 1995, pp. 1385-1388
Citations number
9
Categorie Soggetti
Crystallography
Journal title
Acta crystallographica. Section C, Crystal structure communications → ACNP
ISSN journal
01082701
Volume
51
Year of publication
1995
Part
7
Pages
1385 - 1388
Database
ISI
SICI code
0108-2701(1995)51:<1385:31MA>2.0.ZU;2-9
Abstract
The title compounds, C6H6N4O2S.H2O, (I), and C10H13N3O2S, (II), were p repared for structural and pharmacological comparison with diazoxide, an antihypertensive agent. The crystal structure determinations show t hat the 4H- (rather than the 2H-) tautomeric form is preferentially ad opted by these pyridothiadiazine derivatives in the solid state, as ha s also been found for diazoxide and other 1,2,4-thiadiazine 1,1-dioxid e analogues. The tert-butyl moiety in (II) is slightly disordered.