GENETIC-BASIS OF IGE RESPONSIVENESS - RELEVANCE TO THE ATOPIC DISEASES

Authors
MARSH DG NEELY JD BREAZEALE DR GHOSH B FREIDHOFF LR SCHOU C BEATY TH
Citation
Dg. Marsh et al., GENETIC-BASIS OF IGE RESPONSIVENESS - RELEVANCE TO THE ATOPIC DISEASES, International archives of allergy and immunology, 107(1-3), 1995, pp. 25-28
Citations number
19
Categorie Soggetti
Allergy,Immunology
Journal title
International archives of allergy and immunology → ACNP
ISSN journal
10182438
Volume
107
Issue
1-3
Year of publication
1995
Pages
25 - 28
Database
ISI
SICI code
1018-2438(1995)107:1-3<25:GOIR-R>2.0.ZU;2-D
Abstract
Genetic analysis of 170 subjects in 11 extended Amish families reveale d evidence for linkage of five markers in chromosome 5q31.1 with a gen e controlling total serum IgE levels. No linkage was found between the se markers and specific IgE antibody levels. Analysis of total IgE wit hin a subset of 128 IgE-antibody-negative sib pairs confirmed evidence for linkage to 5q31.1, especially IL4 (p=4x10(-6)). These and other d ata suggest that IL4 or a nearby gene regulates IgE production in a no n-antigen-specific (noncognate) fashion and provide evidence for a pos sible link between asthma and the IL4 gene.