E. Chaikin et al., THE INCAPABILITY OF INTERLEUKIN-4 TO INDUCE AP-1 ACTIVITY IN MURINE MAST-CELLS, International archives of allergy and immunology, 107(1-3), 1995, pp. 57-59
The results presented in this study shed new light on the molecular me
chanism responsible for the control of interleukin (IL)-3- and IL-4 me
diated mast cell proliferation. By measurements of AP-1 DNA-binding ac
tivity, it was found that IL-3 induced such activity while IL-4 did no
t. This difference in the pattern of AP-1 DNA-binding activity induced
by each lymphokine indicates the differential involvement of AP-1 in
the different proliferative responses of mast cells to IL-3 and IL-4.