THE INCAPABILITY OF INTERLEUKIN-4 TO INDUCE AP-1 ACTIVITY IN MURINE MAST-CELLS

Authors
CHAIKIN E HAKEEM I RAZIN E
Citation
E. Chaikin et al., THE INCAPABILITY OF INTERLEUKIN-4 TO INDUCE AP-1 ACTIVITY IN MURINE MAST-CELLS, International archives of allergy and immunology, 107(1-3), 1995, pp. 57-59
Citations number
8
Categorie Soggetti
Allergy,Immunology
Journal title
International archives of allergy and immunology → ACNP
ISSN journal
10182438
Volume
107
Issue
1-3
Year of publication
1995
Pages
57 - 59
Database
ISI
SICI code
1018-2438(1995)107:1-3<57:TIOITI>2.0.ZU;2-P
Abstract
The results presented in this study shed new light on the molecular me chanism responsible for the control of interleukin (IL)-3- and IL-4 me diated mast cell proliferation. By measurements of AP-1 DNA-binding ac tivity, it was found that IL-3 induced such activity while IL-4 did no t. This difference in the pattern of AP-1 DNA-binding activity induced by each lymphokine indicates the differential involvement of AP-1 in the different proliferative responses of mast cells to IL-3 and IL-4.