CEFTIBUTEN CONCENTRATIONS IN HUMAN TONSILLAR TISSUE

In a study designed to determine ceftibuten concentrations in tonsilla r tissue, subjects scheduled to undergo tonsillectomy were administere d 400 mg of ceftibuten in a single oral dose, Between 2 and 24 h after the dose was given, tonsillar tissue samples were taken during surger y and assayed for ceftibuten. Mean concentrations in tonsillar tissue 4.4 h and 24.6 h after the 400 mg dose were 5.3 +/- 2.7 and 0.3 +/- 0. 3 mg/g, respectively. Concurrent mean serum concentrations were 7.42 /- 1,66 and 0.15 +/- 0.13 mg/ml, respectively. The apparent half-life of drug in the tissue was 5.3 h, The presence of high ceftibuten conce ntrations in tonsillar tissue suggests that a once-daily regimen may b e effective in treating tonsillitis and pharyngitis.