COGNITIVE-FUNCTIONING IN EXPERIMENTAL HYPOGLYCEMIA ASSESSED WITH EVENT-RELATED POTENTIALS

COGNITIVE effects of experimentally induced hypoglycaemia were investi gated by event-related brain potentials (ERPs) in auditory and visual classification In a cross-over design eight healthy male subjects (age 22-27 years) were studied under control conditions or following admin istration of 0.15 IU insulin kg(-1). The ERPs showed preserved early c ortical components, while the N2 component was greatly reduced in both modalities. P3 components did not show an influence of hypoglycemia. These results suggest that the cognitive deficits are due to an impair ment of automatic feature extraction from the stimuli.