PLASMINOGEN ACTIVATION BY INVASIVE HUMAN PATHOGENS

Authors
BOYLE MDP LOTTENBERG R
Citation
Mdp. Boyle et R. Lottenberg, PLASMINOGEN ACTIVATION BY INVASIVE HUMAN PATHOGENS, Thrombosis and haemostasis, 77(1), 1997, pp. 1-10
Citations number
134
Categorie Soggetti
Hematology,"Peripheal Vascular Diseas
Journal title
Thrombosis and haemostasis → ACNP
ISSN journal
03406245
Volume
77
Issue
1
Year of publication
1997
Pages
1 - 10
Database
ISI
SICI code
0340-6245(1997)77:1<1:PABIHP>2.0.ZU;2-B
Abstract
In this review the interaction between invasive human pathogens expres sing plasmin(ogen) receptors and/or producing plasminogen activators w ith the human plasmin(ogen) system is described. Evidence is presented for multiple mechanisms by which human pathogens can acquire a surfac e bound form of plasmin that cannot be regulated by host serpins. The potential importance of these pathways in providing the organisms with the ability to cross tissue barriers is discussed.