FAILURE OF ASPIRIN AND DILTIAZEM TO PREVENT THE FORMATION OF ACUTE CORONARY THROMBI IN DOGS

The aim of the present study was to determine the efficacy of aspirin and diltiazem in preventing the formation of coronary thrombi in dogs. Canine coronary thrombi were produced by inserting a small catheter f illed with collagen powder into the endothelial-injured, partially occ luded left anterior descending corollary artery Neither aspirin (bobs of 30 mg/kg, followed by 100 mg/kg/h by infusion), nor diltiazem (0.1 mg/kg, followed by 0.3 mg/kg/h by infusion) prevented the formation of coronary thrombi. The mortality in aspirin group was significantly hi gher than that in control and diltiazem groups. These results indicate that aspirin and diltiazem do not inhibit thrombus formation in the c anine model of coronary thrombosis.