SYNTHESIS AND PHARMACOLOGICAL PROFILE OF FCE-28654 - A WATER-SOLUBLE AND INJECTABLE ACAT INHIBITOR

Authors
CHIARI A FANCELLI D LOVISOLO PP RADICE A SAVOIA L SEVERINO D GHISELLI G
Citation
A. Chiari et al., SYNTHESIS AND PHARMACOLOGICAL PROFILE OF FCE-28654 - A WATER-SOLUBLE AND INJECTABLE ACAT INHIBITOR, Bioorganic & medicinal chemistry letters, 5(15), 1995, pp. 1581-1586
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
15
Year of publication
1995
Pages
1581 - 1586
Database
ISI
SICI code
0960-894X(1995)5:15<1581:SAPPOF>2.0.ZU;2-J
Abstract
The synthesis and the pharmacological evaluation of FCE 28654, a novel water-soluble ACAT inhibitor, are reported. The compound positively m odifies blood and hepatic cholesterol levels when orally or intravenou sly administered to hypercholesterolemic animals.