SYNTHESIS OF BETA-KETO AND ALPHA,BETA-UNSATURATED N-ACETYLCYSTEAMINE THIOESTERS

Authors
GILBERT IH GINTY M ONEILL JA SIMPSON TJ STAUNTON J WILLIS CL
Citation
Ih. Gilbert et al., SYNTHESIS OF BETA-KETO AND ALPHA,BETA-UNSATURATED N-ACETYLCYSTEAMINE THIOESTERS, Bioorganic & medicinal chemistry letters, 5(15), 1995, pp. 1587-1590
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
15
Year of publication
1995
Pages
1587 - 1590
Database
ISI
SICI code
0960-894X(1995)5:15<1587:SOBAAN>2.0.ZU;2-K
Abstract
Methods for the synthesis of N-acetylcysteamine thioesters of beta-ket o and alpha,beta-unsaturated acids which avoid problems associated wit h methods requiring the intermediacy of the free acids are described, along with a convenient method for the removal of excess thiol from re action mixtures using copper sulphate impregnated silica.