EFFECTS OF 10-N-BUTYL-3-METHYL-5-DEAZAFLAVO-6,9-QUINONE (5-DFIQ) ON MITOCHONDRIAL RESPIRATION

Authors
KONOBU K TOYOMOTO M MURAI Y YAMAMOTO E KIMACHI T BESSHO K YONEDA F
Citation
K. Konobu et al., EFFECTS OF 10-N-BUTYL-3-METHYL-5-DEAZAFLAVO-6,9-QUINONE (5-DFIQ) ON MITOCHONDRIAL RESPIRATION, Bioorganic & medicinal chemistry letters, 5(15), 1995, pp. 1601-1604
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
15
Year of publication
1995
Pages
1601 - 1604
Database
ISI
SICI code
0960-894X(1995)5:15<1601:EO1(OM>2.0.ZU;2-L
Abstract
10-n-Butyl-3-methyl-5-deazaflavo-6,9-quinone (5-dFlQ) significantly st imulated the state 4 respiration in mitochondria in a concentration-de pendent manner. The respiration inhibited by rotenone and antimycin A was recovered by the addition of 5-dFlQ. These facts suggest that 5-dF lQ acts as electron carriers such as flavins or ubiquinone in the mito chondrial respiratory chain and forms a new pathway for electron trans fer.