PALLADIUM-CATALYZED SYNTHESIS OF (E)-5-(2-ACYLVINYL)-2'-DEOXYURIDINESAND THEIR ANTIVIRAL AND CYTOTOXIC ACTIVITIES

Authors
KUNDU NG MAHANTY JS SPEARS CP ANDREI G SNOECK R BALZARINI J DECLERCQ E
Citation
Ng. Kundu et al., PALLADIUM-CATALYZED SYNTHESIS OF (E)-5-(2-ACYLVINYL)-2'-DEOXYURIDINESAND THEIR ANTIVIRAL AND CYTOTOXIC ACTIVITIES, Bioorganic & medicinal chemistry letters, 5(15), 1995, pp. 1627-1632
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
15
Year of publication
1995
Pages
1627 - 1632
Database
ISI
SICI code
0960-894X(1995)5:15<1627:PSO(>2.0.ZU;2-G
Abstract
5-Iodo-2'-deoxyuridine was converted to (E)-5-(2-acylvinyl)-2'-deoxyur idines by palladium-catalyzed reactions in excellent yields. Compound 2 [(E)-5-(2-benzoylvinyl)-2'-deoxyuridine] had a weak activity against tumor cell lines. In contrast to BVDU, compound 2 and its (E)-5-[2-(p -methoxybenzoyl)vinyl] counterpart (compound 3) were inactive against HSV-1 and VZV.