INHIBITION OF METALLOPROTEINASE BY FUTOENONE DERIVATIVES

Authors
YEH LA CHEN J BACULI F GINGRICH DE SHEN TY
Citation
La. Yeh et al., INHIBITION OF METALLOPROTEINASE BY FUTOENONE DERIVATIVES, Bioorganic & medicinal chemistry letters, 5(15), 1995, pp. 1637-1642
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
15
Year of publication
1995
Pages
1637 - 1642
Database
ISI
SICI code
0960-894X(1995)5:15<1637:IOMBFD>2.0.ZU;2-I
Abstract
Futoenone and a series of its derivatives have shown inhibitory activi ties against matrix metalloproteinases. The molecular modelings of the se compounds indicate the preferred binding of the P2' site of the enz ymes.