SYNTHESIS OF THYMIDINE DIMERS CONTAINING A NEW INTERNUCLEOSIDIC AMIDELINKAGE AND THEIR INCORPORATION INTO OLIGODEOXYRIBONUCLEOTIDES

Authors
DENAPOLI L IADONISI A MONTESARCHIO D VARRA M PICCIALLI G
Citation
L. Denapoli et al., SYNTHESIS OF THYMIDINE DIMERS CONTAINING A NEW INTERNUCLEOSIDIC AMIDELINKAGE AND THEIR INCORPORATION INTO OLIGODEOXYRIBONUCLEOTIDES, Bioorganic & medicinal chemistry letters, 5(15), 1995, pp. 1647-1652
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
15
Year of publication
1995
Pages
1647 - 1652
Database
ISI
SICI code
0960-894X(1995)5:15<1647:SOTDCA>2.0.ZU;2-4
Abstract
The synthesis of thymidine dimers 5a,b containing a chiral carbon in t he propionamide internucleosidic linkage is described. These new epime ric dimers were incorporated in oligodeoxyribonucleotides and the melt ing temperature (Tm) with complementary DNA and RNA as well as the res istence of the single strand against exonuclease were determined.