N-METHYL AND L)IMINO]]BIS(7,8-DIHYDRO-5-BETA-METHYL-MORPHINONE) MET-TAMO AND N-CPM-MET-TAMO - SYNTHESIS AND OPIOID BINDING-PROPERTIES

Authors
BIDLACK JM KAPLAN RA SEBASTIAN A SEYEDMOZAFFARI A HUTCHINSON I ARCHER S
Citation
Jm. Bidlack et al., N-METHYL AND L)IMINO]]BIS(7,8-DIHYDRO-5-BETA-METHYL-MORPHINONE) MET-TAMO AND N-CPM-MET-TAMO - SYNTHESIS AND OPIOID BINDING-PROPERTIES, Bioorganic & medicinal chemistry letters, 5(15), 1995, pp. 1695-1700
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
15
Year of publication
1995
Pages
1695 - 1700
Database
ISI
SICI code
0960-894X(1995)5:15<1695:NALM>2.0.ZU;2-O
Abstract
MET-TAMO and N-CPM-MET-TAMO were prepared by the same procedure used f or the corresponding 5-desmethyl compounds, TAMO and N-CPM-TAMO, excep t that a new procedure was employed to synthesize the intermediate, 14 beta-amino-7,8-dihydromorphinone. Both MET-TAMO and N-CPM-MET-TAMO pr oduced wash-resistant inhibition of mu, delta and kappa binding but we re more potent at the mu receptor.