17-BETA-HYDROXYWORTMANNIN - A POTENT INHIBITOR OF BONE-RESORPTION ANDPHOSPHATIDYLINOSITOL-3-KINASE

Authors
DODGE JA BRYANT HU KIM J MATTER WF NORMAN BH SRINIVASAN U VLAHOS CJ SATO M
Citation
Ja. Dodge et al., 17-BETA-HYDROXYWORTMANNIN - A POTENT INHIBITOR OF BONE-RESORPTION ANDPHOSPHATIDYLINOSITOL-3-KINASE, Bioorganic & medicinal chemistry letters, 5(15), 1995, pp. 1713-1718
Citations number
31
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
15
Year of publication
1995
Pages
1713 - 1718
Database
ISI
SICI code
0960-894X(1995)5:15<1713:1-APIO>2.0.ZU;2-G
Abstract
Structure-function studies on the natural product wortmannin have iden tified a 17 beta-hydroxy derivative as a potent inhibitor of osteoclas t function in both cell and animal models. Mechanistic studies indicat e osteoclast differentiation is dramatically affected by this class of compounds. Interestingly, comparable potency trends for resorption an d phosphatidylinositol-3-kinase inhibition were also observed.